IFI207, a young and fast-evolving antiviral factor, stabilizes STING
Moran, E. A.; Salas-Briceno, K.; Aguilera, A.; Keane, T.; Adams, D.; Lilue, J.; Ross, S. R.
Show abstract
Mammalian ALR proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to host innate immunity. ALRs are encoded at a single genetic locus. In mice, the Alr locus is highly polymorphic at the sequence and copy number level. We suggest that one rapidly evolving member of the Alr family, Ifi207, was introduced to the Mus genome by a recent recombination event. Ifi207 has a large, distinctive repeat region that differs in sequence and length in different Mus strains. We show that IFI207 plays a key role in the STING-mediated response to cGAMP, DNA, and MLV, and that IFI207 controls MLV infection in vivo. Uniquely, IFI207 acts by stabilizing STING protein via its repeat region. Our studies suggest that under the pressure of host-pathogen coevolution, in a dynamic locus such as the Alr, recombination between gene family members creates new genes with novel and essential functions that play diverse roles in biological processes.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway 100%
- HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 96%
- HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrest 96%
Similar papers in this journal
Similar papers in this journal
- Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen 96%
- MDA5 autoimmune disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA 95%
- The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection 95%
Similar papers in this journal
- Mouse B2 SINE elements function as IFN-inducible enhancers 96%
- Human immunodeficiency virus-1 induces host genomic R-loop and preferentially integrates its genome near the R-loop regions 96%
- Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicity 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.