Cytoplasmic Aggregation of RPB1 Predicts Failure of Neoadjuvant Chemotherapy
Nagy-Miko, B.; Nemeth-Szatmari, O.; Farago-Meszaros, R.; Csokasi, A.; Bognar, B.; Ördög, N.; Borsos, B. N.; Majoros, H.; Ujfaludi, Z.; Olah-Nemeth, O.; Nikolenyi, A.; Dobi, A.; Koszo, R.; Santha, D.; Lazar, G.; Simonka, Z.; Paszt, A.; Ormandi, K.; Pankotai, T.; Boros, I. M.; Villanyi, Z.; Vörös, A.
Show abstract
We aimed to investigate the contribution of co-translational protein aggregation to the chemotherapy resistance of tumor cells. Increased co-translational protein aggregation reflects altered translation regulation that may have the potential to buffer transcription under genotoxic stress. As an indicator for such event, we followed cytoplasmic aggregation of RPB1, the aggregation prone largest subunit of RNA polymerase II, in biopsy samples taken from patients with invasive carcinoma of no special type. RPB1 frequently aggregates co-translationally in the absence of proper HSP90 chaperone function or in ribosome mutant cells as revealed formerly in yeast. We found that cytoplasmic foci of RPB1 occur in larger sizes in tumors that showed no regression after therapy. Based on these results, we propose that monitoring the cytoplasmic aggregation of RPB1 may be suitable for determining - from biopsy samples taken before treatment - the effectiveness of neoadjuvant chemotherapy.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Development of a Single Molecule Counting Assay to Differentiate Chromophobe Renal Cancer and Oncocytoma in Clinics 96%
- COL7A1 expression improves prognosis prediction for patients with clear cell renal cell carcinoma atop of stage 95%
- A novel molecular analysis approach in colorectal cancer suggests new treatment opportunities 94%
Similar papers in this journal
- Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder 95%
- Oncoprotein 18 is necessary for malignant cell proliferation in bladder cancer cells and serves as a G3-specific non-invasive diagnostic marker candidate in urinary RNA 95%
- miRNA profiling in renal carcinoma suggest the existence of a group of pro-angionenic tumors in localized clear cell renal carcinoma 94%
Similar papers in this journal
- Data independent acquisition mass spectrometry (DIA-MS) analysis of FFPE rectal cancer samples offers in depth proteomics characterization of response to neoadjuvant chemoradiotherapy 94%
- Optimized transcriptional signature for evaluation of MEK/ERK pathway baseline activity and long-term modulations in ovarian cancer 93%
- Pro-apoptotic and anti-invasive properties underscore the tumor suppressing impact of myoglobin on subset of human breast cancer cells 93%
Similar papers in this journal
- Patient stratification of clear cell renal cell carcinoma using the global transcription factor activity landscape derived from RNA-seq data 95%
- Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets 94%
- BNIP3 upregulation characterizes cancer cell subpopulation with increased fitness and proliferation 93%
Similar papers in this journal
- Loss of HOXB13 expression in neuroendocrine prostate cancer 94%
- Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases 94%
- Single-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.