Targeted Sequencing of Pancreatic Ductal Adenocarcinoma Tissue
Thillai, K.; Benzing, C.; Quaglia, A.; Sarker, D.; Wells, C.
Show abstract
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer and the majority of patients present with metastatic disease. Metastatic spread requires a reorganisation of the actin cytoskeleton, a process that is dependent on the Rho family GTPases and their interaction with subsequent downstream effectors. The p21 activated kinases (also known as the PAKs) are effectors of Rho GTPases Cdc42 and Rac and play key roles in cell migration and survival. PAK4 is overexpressed in PDAC and can reciprocally activate the PI3K pathway. Hepatocyte growth factor (HGF), via c-Met, is an established activator of PAK4 and the PI3K pathway and may promote PDAC invasion. Next generation sequencing (NGS) was performed on 31 PDAC tissue using a pre-determined targeted panel to attempt to identify novel mutations in the PAK: PI3K pathway. Targeted NGS identified several recurrent mutations including 5 PAK4 mutations in PDAC tissue.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Comparative Immune profiling in Pancreatic Ductal Adenocarcinoma Progression Among South African patients 94%
- PDAC-ANN: an artificial neural network to predict Pancreatic Ductal Adenocarcinoma based on gene expression 94%
- The Concept of Stroma AReactive Invasion Front Areas (SARIFA) as a New Prognostic Biomarker for Lipid-driven Cancers Holds True in Pancreatic Ductal Adenocarcinoma 93%
Similar papers in this journal
- Prevalence and spectrum of germline BRCA1 and BRCA2 mutations in multiethnic cohort of breast cancer patients in Brunei Darussalam 93%
- Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma 93%
- Comprehensive cancer-oriented biobanking resource of human samples for studies of post-zygotic genetic variation involved in cancer predisposition 93%
Similar papers in this journal
- Deep sequencing of early T stage colorectal cancers reveals disruption of homologous recombination repair in microsatellite stable tumours with high mutational burdens 94%
- Ethnicity-Specific Molecular Alterations in MAPK and JAK/STAT Pathways in Early-Onset Colorectal Cancer 93%
- Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations 93%
Similar papers in this journal
Similar papers in this journal
- Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets 93%
- Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures and serum samples from a European Caucasian population 92%
- Factors affecting COVID-19 outcomes in cancer patients - A first report from Guys Cancer Centre in London 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.