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Different rules for binocular combination of luminance flicker in cortical and subcortical pathways

Segala, F. G.; Bruno, A.; Aung, M. T.; Wade, A. R.; Baker, D. H.

2023-02-15 neuroscience
10.1101/2023.01.11.523568 bioRxiv
Show abstract

1How does the human brain combine information across the eyes? It has been known for many years that cortical normalisation mechanisms implement ocularity invariance: equalising neural responses to spatial patterns presented either monocularly or binocularly. Here we used a novel combination of electrophysiology, psychophysics, pupillometry and computational modelling to ask whether this invariance also holds for flickering luminance stimuli with no spatial contrast. We find dramatic violations of ocularity invariance for these stimuli, both in cortex and also in the subcortical pathways that govern pupil diameter. Specifically, we find substantial binocular facilitation in both pathways with the effect being strongest in cortex. Near-linear binocular additivity (instead of ocularity invariance) was also found using a perceptual luminance matching task. Ocularity invariance is therefore not a ubiquitous feature of visual processing, and the brain appears to repurpose a generic normalisation algorithm for different visual functions by adjusting the amount of interocular suppression.

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