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Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT)

Ma, R.; Velusamy, A.; Rashid, A.; Deal, B. R.; Chen, W.; Petrich, B.; Li, R.; Salaita, K.

2023-01-11 bioengineering
10.1101/2023.01.10.523449 bioRxiv
Show abstract

Flow cytometry is routinely used to measure single-cell gene expression by staining cells with fluorescent antibodies and nucleic acids. Here we present Tension-activated Cell Tagging (TaCT) to fluorescently label cells based on the magnitude of molecular force transmitted through cell adhesion receptors. As a proof-of-concept, we analyzed fibroblasts and mouse platelets after TaCT using conventional flow cytometry.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.