Preoperative Intensification Treatment in Patients with Rectal Adenocarcinoma - A Standardization of Clinical Practice

2023-01-09 oncology Title + abstract only

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Neoadjuvant radiotherapy with concurrent fluoropyrimidines followed by surgery is considered the standard-of-care in locally advanced rectal cancer (LARC). Neoadjuvant chemo-radiotherapy (CRT) is associated with a pathological complete response (pCR) rate of 11-18%. Intensification of neoadjuvant treatment can lead to higher rates of tumor resectability and pCR, although the best therapeutic sequence is unknown. This is a prospective, single arm study which aims to standardize institutional cli...