A multi-tissue single-cell tumor microenvironment atlas reveals myeloid-derived cell states with significant impact on clinical outcome
Maklouf, G. R.; Guimaraes, G. R.; Teixeira, C. E.; Pretti, M. A. M.; de Oliveira Santos, L.; Tessarollo, N. G.; Toledo, N. E.; Falchetti, M.; Dimas, M. M.; Serain, A. F.; Bastos, N. C.; de Macedo, F. C.; Rodrigues, F. R.; da Silva, J. L.; Lummertz-Rocha, E.; Chaves, C. B. P.; de Melo, A. C.; Moraes-Vieira, P. M. M.; Mori, M. A.; Boroni, M.
Show abstract
Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment response due to their remarkable plasticity and tumorigenic behaviors. We integrated single-cell RNA-Sequencing datasets from seven different cancers, resulting in a comprehensive collection of 29 MDC subpopulations in the tumor microenvironment (TME). Distinguishing resident-tissue from monocyte-derived macrophages, we discovered a resident-tissue-like subpopulation within monocyte-derived macrophages. Additionally, hypoxia-driven macrophages emerged as a prominent TME component. Deconvolution of these profiles revealed five subpopulations as independent prognostic markers across various cancer types. Validation in large cohorts confirmed the FOLR2-expressing macrophage association with poor clinical outcomes in ovarian and triple-negative breast cancer. Moreover, the marker TREM2, commonly used to define immunosuppressive tumor-associated macrophages, cannot solely predict cancer prognosis, as different polarization states of macrophages express this marker in a context-dependent manner. This comprehensive MDC atlas offers valuable insights and a foundation for novel analyses, advancing strategies for treating solid cancers.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids 97%
- Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals an invasive tumor vasculature phenotype 97%
- Mapping the Immune Landscape of Clear Cell Renal Cell Carcinoma by Single-Cell RNA-seq 95%
Similar papers in this journal
- Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer 97%
- Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases 97%
- Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysis 95%
Similar papers in this journal
- Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma 96%
- In vitro models to mimic tumor endothelial cell-mediated immune cell reprogramming in lung adenocarcinoma 95%
- Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.