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A Bayesian network-based framework to uncover the causal effects of genes on complex traits based on GWAS data

2022-12-27 genetic and genomic medicine Title + abstract only
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Deciphering the relationships between genes and complex traits could help us better understand the biological mechanisms leading to phenotypic variations and disease onset. Univariate gene-based analyses are widely used to characterize gene-phenotype relationships, but are subject to the influence of confounders. Furthermore, while some genes directly contribute to traits variations, others may exert their effects through other genes. How to quantify individual genes direct and indirect effects ...

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