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Quantitative multi-organ proteomics of fatal COVID-19 uncovers tissue-specific effects beyond inflammation

2022-12-22 infectious diseases Title + abstract only
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SARS-CoV-2 directly damages lung tissue via its infection and replication process and indirectly due to systemic effects of the host immune system. There are few systems-wide, untargeted studies of these effects on the different tissues of the human body and nearly all of them base their conclusions on the transcriptome. Here we developed a parallelized mass spectrometry (MS)-based proteomics workflow allowing the rapid, quantitative analysis of hundreds of virus-infected and FFPE preserved tiss...

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