Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury
Renz, P. V.; Surbek, D.; Haesler, V.; Tscherrig, V.; Huang, E. J.; Chavali, M.; Liddelow, S. A.; Rowitch, D.; Schoeberlein, A.; Brosius Lutz, A. R.
Show abstract
The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing the formation of a C3-expressing neuroinflammatory reactive astrocyte sub-state rescues myelination and behavioral deficits. We further demonstrate the presence of C3-expressing reactive astrocytes in human WMI. Our data point to these cells as putative drivers of myelination failure in WMI and a potentially promising therapeutic target.
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