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Genetic relationships and causality between overall and central adiposity and breast, prostate, lung and colorectal cancer
2022-12-19
endocrinology
Title + abstract only
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OBJECTIVEDiverse measures of obesity relate to cancer risk differently. Here we assess the relationship between overall and central adiposity and cancer. METHODSWe constructed z-score weighted polygenic scores (PGS) for two obesity-related phenotypes; body mass index (BMI) and BMI adjusted waist-to-hip ratio (WHRadjBMI) and tested for their association with five cancers in the UK Biobank: overall breast (BrC), post-menopausal breast (PostBrC), prostate (PrC), colorectal (CrC) and lung (LungC) c...
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