Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain
Zhang, X.; Xiao, G.; Johnson, C. A.; Cai, Y.; Horowitz, Z.; Mennicke, C.; Coffey, R.; Haider, M.; Threadgill, D. W.; Eliscu, R.; Oldham, M. C.; Greenbaum, A. C.; Ghashghaei, H. T.
Show abstract
The Epidermal growth factor receptor (EGFR) plays a role in cell proliferation and differentiation during healthy development and tumor growth, however its requirement for brain development remains unclear. Here we used a conditional mouse allele for Egfr to examine its contributions to perinatal forebrain development at the tissue level. Subtractive bulk ventral and dorsal forebrain deletions of Egfr uncovered significant and permanent decreases in oligodendrogenesis and myelination in the cortex and corpus callosum. Additionally, an increase in astrogenesis or reactive astrocytes in effected regions was evident in response to cortical scarring. Sparse deletion using Mosaic Analysis with Double Markers (MADM) surprisingly revealed a regional requirement for EGFR in rostrodorsal, but not ventrocaudal glial lineages including both astrocytes and oligodendrocytes. The EGFR-independent ventral glial progenitors may compensate for the missing EGFR-dependent dorsal glia in the bulk Egfr-deleted forebrain, potentially exposing a regenerative population of gliogenic progenitors in the mouse forebrain.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone 97%
- Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human 96%
- Translatomic database of cortical astroglia across male and female mouse development reveals two distinct developmental phenotypes 96%
Similar papers in this journal
- PTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal Features 97%
- The Lateral/Caudal Ganglionic Eminence Makes a Limited Contribution to Cortical Oligodendrocytes 96%
- Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation 96%
Similar papers in this journal
- The neocortical progenitor specification program is established throughcombined modulation of SHH and FGF signaling 96%
- Neuregulin1 nuclear signaling influences adult neurogenesis and regulates a schizophrenia susceptibility gene network within the mouse dentate gyrus. 96%
- Sustained ErbB activation causes demyelination and hypomyelination by driving necroptosis of mature oligodendrocytes and apoptosis of oligodendrocyte precursor cells 96%
Similar papers in this journal
- Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia 96%
- Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation through Metabolic and Synaptic Regulation 95%
- Brain injuries and complex motor learning suppress Olig2 in a subpopulation of oligodendrocyte precursor cells 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.