NK-cell educating KIR/HLA combinations impact survival in anti-PD-L1 treated cancer patients
Roe, D.; Rosoff, H.; Ruan, D. F.; Khan, Z.; Dogra, P.; Carroll, J.; Hunkapiller, J.; Mohindra, R.; Srivastava, M. K.; Nabet, B. Y.; Chandler, G. S.; Albert, M. L.; McCarthy, M. I.; Mellman, I.; Horowitz, A.; Hammer, C.
Show abstract
Natural killer (NK) cells are educated through the binding of killer immunoglobulin like receptors (KIR) to human leukocyte antigen (HLA) proteins, but it is unknown whether the presence of these highly diverse KIR/HLA interactions influence responses to immunotherapy in solid tumors. We report herein two observations that shed light on NK cell function and abundance in anti-tumor immune responses. In patients with non-small cell lung cancer treated with anti-PD-L1 therapy, we found that individuals carrying HLA-C1 and HLA-Bw4 alleles and the genes coding for their receptors KIR2DL3 and KIR3DL1 showed improved overall survival (OS). Combined with our second finding that NK cell infiltration was independently associated with improved OS, our findings have important implications for precision medicine approaches and the development of NK cell-based therapies.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response 95%
- Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma 94%
- MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer 94%
Similar papers in this journal
- Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction 93%
- Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer 92%
- Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments 92%
Similar papers in this journal
- Elucidating the heterogeneity of immunotherapy response and immune-related toxicities by longitudinal ctDNA and immune cell compartment tracking in lung cancer 96%
- Myeloid cell-associated resistance to PD-1/PD-L1 blockade in urothelial cancer revealed through bulk and single-cell RNA sequencing 95%
- Immunogenicity of non-canonical HLA-tumor ligands identified through proteogenomics 93%
Similar papers in this journal
- Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer 94%
- An mRNA-encoded, long-lasting Interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers 94%
- Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators 94%
Similar papers in this journal
- A new highly-specific Natural Killer cell-specific gene signature predicting recurrence in colorectal cancer patients. 95%
- T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H 95%
- A three-gene expression score for predicting clinical benefit to anti-PD-1 blockade in advanced renal cell carcinoma 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.