Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes
Hofford, R. S.; Meckel, K. R.; Wang, W.; Kim, M.; Godino, A.; Lam, T. T.; Kiraly, D.
Show abstract
Opioid use disorder (OUD) is a public health crisis currently being exacerbated by increased rates of use and overdose of synthetic opioids, primarily fentanyl. Therefore, the identification of novel biomarkers and treatment strategies to reduce problematic fentanyl use and relapse to fentanyl taking is critical. In recent years, there has been a growing body of work demonstrating that the gut microbiome can serve as a potent modulator of the behavioral and transcriptional responses to both stimulants and opioids. Here, we advance this work to define how manipulations of the microbiome drive fentanyl intake and fentanyl seeking in a translationally relevant drug self-administration model. Additionally, we utilize global proteomic analysis of the nucleus accumbens following microbiome manipulation and fentanyl administration to define how microbiome status alters the functional proteomic landscape in this key limbic substructure. These findings establish clear relevance for gut-brain signaling in OUD, and lay foundations for further translational work in this space.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking 97%
- Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Mesolimbic Dopamine System 96%
- Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure 95%
Similar papers in this journal
- Fentanyl reinforcement history has sex-specific effects on multi-step decision-making 95%
- Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration 95%
- Female rats consume and prefer oxycodone more than males in a chronic two-bottle oral voluntary choice paradigm 95%
Similar papers in this journal
- Effect of selective lesions of nucleus accumbens μ-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with novel Oprm1-Cre knock-in rats 94%
- Vaporized cannabis extracts have reinforcing properties and support conditioned drug-seeking behavior in rats 94%
- The mesolimbic dopamine signatures of relapse to alcohol-seeking 94%
Similar papers in this journal
- Dissociable dorsal medial prefrontal cortex ensembles are necessary for cocaine seeking and fear conditioning in mice 94%
- Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior 93%
- Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.