Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampus
Nilssen, E. S.; Jacobsen, B.; Doan, T. P.; Girao, P. J. B.; Witter, M. P.
Show abstract
The functionally different lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC) are strongly interconnected. The role of this interconnectivity in view of their functional differences is not known. Here we provide details on a circuit that directly connects MEC to neurons in the superficial layers of LEC. Using a combination of anatomical tracing experiments and in vitro electrophysiological recordings in the mouse, we report that axons from MEC somatostatin-expressing GABAergic neurons densely distribute in layer I of LEC, where they drive strong and near selective inhibition of principal neurons in layer IIa. This inhibitory pathway is accompanied by MEC glutamatergic axons that innervate multiple layers of LEC and preferentially synapse onto principal neurons in layers IIb and III. These findings indicate that excitatory and inhibitory projections from MEC may separately regulate the activity of different populations of hippocampal-projecting principal neurons in LEC.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1 98%
- Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells 97%
- Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1 97%
Similar papers in this journal
Similar papers in this journal
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse 98%
- Synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract 97%
- Recurrent circuits amplify corticofugal signals and drive feed-forward inhibition in the inferior colliculus 97%
Similar papers in this journal
- Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behavior 97%
- Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output 96%
- Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.