The Cation/H+ exchanger OsCAX2 is involved in cadmium tolerance and accumulation through vacuolar sequestration in rice
Zou, W.; Zhan, J.; Meng, L.; Chen, Y.; Chen, D.; Zhang, M.; He, H.; Chen, J.; Ye, G.
Show abstract
Excessive cadmium (Cd) in rice grains is a serious food safety problem. The development of Cd-safe varieties requires the identification of germplasms and genes with major effect on Cd accumulation but without negative effects on other important traits. Here, we reported that OsCAX2, a member of the rice Cation/H+ exchanger (CAX) family, is an important Cd transporter. OsCAX2 encodes a tonoplast-localized protein and is strongly upregulated by Cd, mainly expresses in root exodermis, parenchyma in cortex, endodermis and stele cells. Depletion of OsCAX2 resulted in enhanced Cd sensitivity and root-to-shoot translocation in rice, while overexpression of OsCAX2 significantly increased Cd tolerance and reduced Cd transport by promoting root Cd influx and vacuolar storage, which ultimately reduced Cd transport via xylem. OsCAX2 also had significant effects on tissues/organs distribution of Cd but had no effects on grain yield and agronomic traits. Importantly, the OsCAX2 overexpressing lines had more than 70% lower grain Cd accumulation, increased iron (Fe), zinc (Zn) and manganese (Mn) and reduced copper (Cu) accumulation. Therefore, OsCAX2 is an ideal gene for developing Cd-safe rice varieties via transgenic approach.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Rice NIN-LIKE PROTEIN 1 Rapidly Responds to Nitrogen Deficiency and Improves Yield and Nitrogen Use Efficiency 97%
- Natural variations in the P-type ATPase heavy metal transporter ZmCd1 controlling cadmium accumulation in maize grains 96%
- IRONMAN interacts with OsHRZ1 and OsHRZ2 to maintain Fe homeostasis 96%
Similar papers in this journal
- The transcription factor OsbZIP48 governs rice responses to zinc deficiency 98%
- Auxin Plays a Role in the Adaptation of Rice to Anaerobic Germination and Seedling Establishment 97%
- Protein lysine methylation is involved in modulating the response of sensitive and tolerant Arabidopsis species to cadmium stress 95%
Similar papers in this journal
- Multifaceted roles of rice ABA/stress-induced intrinsically disordered proteins in augmenting drought resistance 96%
- Auxin-responsive (phospho)proteome analysis reveals regulation of cell cycle and ethylene signaling during rice crown root development 95%
- The full-length transcriptome of Spartina alterniflora reveals the complexity of high salt tolerance in monocotyledonous halophyte 94%
Similar papers in this journal
- Engineering rice Nramp5 modifies cadmium and manganese uptake selectivity using yeast assay system 96%
- Evidences for a nutritional role of iodine in plants 94%
- Genome-wide association study reveals complex genetic architecture of cadmium and mercury accumulation and tolerance traits in Medicago truncatula 94%
Similar papers in this journal
- OsNLP3/4-OsRFL module regulates nitrogen-promoted panicle architecture in rice 95%
- Ustilaginoidea virens suppresses floral immunity through promoting GA biosynthesis by the effector SCRE9 94%
- ENHANCED GRAVITROPISM 2 coordinates molecular adaptations to gravistimulation in the elongation zone of barley roots 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.