The Eating Disorders Genetics Initiative (EDGI) United Kingdom
Monssen, D.; Davies, H. L.; Bristow, S.; Kakar, S.; Curzons, S. C. B.; Davies, M. R.; Ahmad, Z.; Bradley, J. R.; Bright, S.; Coleman, J. R.; Glen, K.; Hotopf, M.; Kelly, E. J.; Ter Kuile, A. R.; Malouf, C. M.; Kalsi, G.; Kingston, N.; McAtarsney-Kovacs, M.; Mundy, J.; Peel, A. J.; Palmos, A. B.; Rogers, H. C.; Skelton, M.; Adey, B. N.; Lee, S. H.; Virgo, H.; Quinn, T.; Price, T.; Zvrskovec, J.; Eley, T. C.; Treasure, J.; Hubel, C.; Breen, G.
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ObjectiveThe Eating Disorders Genetics Initiative United Kingdom (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental Health BioResource, aims to deepen our understanding of the environmental and genetic aetiology of eating disorders. EDGI UK launched in February 2020 and is partnered with the UK eating disorders charity, Beat. There are multiple EDGI branches worldwide. MethodEDGI UK recruits via media and clinical services. Anyone living in England, at least 16 years old, with a lifetime probable or clinical eating disorder is eligible to sign up online: edgiuk.org. Participants complete online questionnaires, donate a saliva sample for genetic analysis, and consent to medical record linkage and recontact for future studies. ResultsAs of September 2022, EDGI UK has recruited 8,397 survey participants: 98% female, 93% white, 97.7% cisgender, 67% heterosexual, and 52% have a university degree. Half (51.7%) of participants have returned their saliva kit. The most common diagnoses are anorexia nervosa (42.7%), atypical anorexia nervosa (31.4%), bulimia nervosa (33.2%), binge-eating disorder (14.6%), and purging disorder (33.5%). ConclusionEDGI UK is the largest UK eating disorders study but needs to increase its diversity, and efforts are underway to do so. It also offers a unique opportunity to accelerate eating disorder research, and collaboration between researchers and participants with lived experience, with unparalleled sample size.
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