A new LD protein, ApoL6 disrupts the Perilipin 1-HSL interaction to inhibit lipolysis
Wang, Y.; Nguyen, H. P.; Xue, P.; Xie, Y.; Yi, D.; Lin, F.; Viscarra, J. A.; Ibe, N. U.; Duncan, R. E.; Sul, H. S.
Show abstract
ApoL6 is a new LD-associated protein containing an apoprotein-like domain, expressed mainly in adipose tissue, specifically in adipocytes. ApoL6 expression is low in fasting but induced upon feeding. ApoL6 knockdown results in smaller LD with lower triglyceride (TAG) content in adipocytes, while ApoL6 overexpression causes larger LD with higher TAG content. We show that ApoL6 effect in adipocytes is by inhibition of lipolysis. While ApoL6, Perilipin 1 (Plin1) and HSL can form a complex on LD, C-terminal domain of ApoL6 directly interacts with Plin1, to compete with Plin1 binding to HSL through Plin1 N-terminal domain, thereby keeping HSL in a "stand by" status. Thus, ApoL6 ablation decreases WAT mass, protecting mice from diet-induced obesity, while adipose overexpression increases WAT mass to bring obesity and insulin resistance with hepatosteatosis, making ApoL6 a potential future target against obesity and diabetes.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function 95%
- Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7 95%
- Ferredoxin 1 is essential for embryonic development and lipid homeostasis 95%
Similar papers in this journal
Similar papers in this journal
- Reducing 14-3-314-3-3ζ expression influences adipocyte maturity and impairs function 96%
- ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioning 96%
- Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice 95%
Similar papers in this journal
Similar papers in this journal
- Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria 92%
- The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: A Mendelian randomization study 92%
- Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.