Large-area electrical imaging having single neuron resolution using 236,880 electrodes CMOS-MEA technology
Suzuki, I.; Matsuda, N.; Han, X.; Noji, S.; Shibata, M.; Nagafuku, N.; Ishibashi, Y.
Show abstract
The electrophysiological technology having a high spatio-temporal resolution at the single-cell level, and noninvasive measurements of large areas provides insights on underlying neuronal function. Here, we used a complementary metal-oxide semiconductor (CMOS)-microelectrode array (MEA) that uses 236,880 electrodes each with an electrode size of 11.22 x 11.22 {micro}m and 236,880 covering a wide area of 5.5 x 5.7 mm in presenting a detailed and single-cell-level neural activity analysis platform for brain slices, human iPS cell-derived cortical networks, peripheral neurons, and human brain organoids. Propagation pattern characteristics between brain regions changes the synaptic strength into compounds based on single-cell time-series patterns, classification based on single DRG neuron firing patterns and compound responses, axonal conduction characteristics and changes to anticancer drugs, and network activities and transition to compounds in brain organoids were extracted. This detailed analysis of neural activity at the single-cell level using our CMOS-MEA provides a new understanding the basic mechanisms of brain circuits in vitro and ex vivo, on human neurological diseases for drug discovery, and compound toxicity assessment.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- An in vitro platform for characterizing axonal electrophysiology of individual human iPSC-derived nociceptors 96%
- Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents 95%
- Development of a Microelectrode Array System for Simultaneous Measurement of Field Potential and Glutamate Release in Brain Slices 94%
Similar papers in this journal
Similar papers in this journal
- Inkube: An all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange 94%
- Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes 94%
- Microfluidics-enabled 96-well perfusion system for high-throughput tissue engineering and long-term all-optical electrophysiology 94%
Similar papers in this journal
- Sapphire-Based Optrode for Low Noise Neural Recording and Optogenetic Manipulation 95%
- Neurotransmitter loaded DNA nanocages as potential therapeutics for α-synuclein based neuropathies in cells and in vivo 92%
- Regulation of dopamine release by tonic activity patterns in the striatal brain slice 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.