Functional characterization of cardiac fibroblasts in response to hemodynamic alteration
shiraishi, m.; suzuki, k.; yamaguchi, a.
Show abstract
Excess deposition of extracellular matrix in the myocardium is a predictor of reduced left ventricular function. Although reducing the hemodynamic load is known to improve myocardial fibrosis, the mechanisms underlying reversal of the fibrosis have not been elucidated. We modeled normal myocardium, fibrotic myocardium and myocardium with reduced fibrosis in vitro. Fibroblasts differentiated into activated or fibrinolytic types in response to the pericellular environment. Comprehensive gene expression analysis of fibroblasts in each in vitro condition showed Selenbp1 to be one of the genes responsible for regulating differentiation of fibroblasts. In vitro knockdown of Selenbp1 enhanced fibroblast activation and inhibited conversion to the fibrinolytic form. In vivo knockdown of Selenbp1 resulted in structural changes in the left ventricle associated with progressive tissue fibrosis and left ventricular diastolic failure. Selenbp1 is involved in regulating fibroblast differentiation and appears to be one of the major molecules regulating collagen turnover in cardiac fibrosis.
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