Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease implicates mediation through GPX3
Panyard, D. J.; Reus, L. M.; Ali, M.; Liu, J.; Deming, Y. K.; Lu, Q.; Kollmorgen, G.; Suridjan, I.; Wild, N.; Visser, P. J.; Bertram, L.; Zetterberg, H.; Blennow, K.; Gobom, J.; Western, D.; Sung, Y. J.; Carlsson, C. M.; Johnson, S. C.; Asthana, S.; Cruchaga, C.; Tijms, B. M.; Engelman, C. D.; Snyder, M. P.
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The recently reported TNIP1/GPX3 locus from AD GWAS studies was investigated. Using proteomics and other functional omics data, we identified evidence for a functional mechanism linking variants in this locus to decreased CSF GPX3 levels as AD progresses, suggesting a new potential target for intervention.
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