DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions
Kugler, V.; Lieb, A.; Guerin, N.; Donald, B. R.; Stefan, E.; Kaserer, T.
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We report an Osprey-based computational protocol to prospectively identify oncogenic mutations that act via disruption of molecular interactions. It is applicable to analyze both protein-protein and protein-DNA interfaces and has been validated on a dataset of clinically relevant mutations. In addition, it was used to predict previously uncharacterized patient mutations in CDK6 and p16 genes, which were experimentally confirmed to impair complex formation.
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