Back

Substantial Neutralization Escape by the SARS-CoV-2 Omicron Variant BQ.1.1

Miller, J.; Hachmann, N.; Collier, A.-r.; Lasrado, N.; Mazurek, C.; Patio, R.; Powers, O.; Surve, N.; Theiler, J.; Korber, B.; Barouch, D. H.

2022-11-02 immunology
10.1101/2022.11.01.514722 bioRxiv
Show abstract

Omicron BA.5 has been the globally dominant SARS-CoV-2 variant and has demonstrated substantial neutralization escape compared with prior variants. Additional Omicron variants have recently emerged, including BA.4.6, BF.7, BA.2.75.2, and BQ.1.1, all of which have the Spike R346T mutation. In particular, BQ.1.1 has rapidly increased in frequency, and BA.5 has recently declined to less than half of viruses in the United States. Our data demonstrate that BA.2.75.2 and BQ.1.1 escape NAbs induced by infection and vaccination more effectively than BA.5. BQ.1.1 NAb titers were lower than BA.5 NAb titers by a factor of 7 in two cohorts of individuals who received the monovalent or bivalent mRNA vaccine boosters. These findings provide the immunologic context for the rapid increase in BQ.1.1 prevalence in regions where BA.5 is dominant and have implications for both vaccine immunity and natural immunity.

Matching journals

The top 7 journals account for 50% of the predicted probability mass.

1
Nature Communications
○ 5641 papers in training set
Top 12%
14.8%
Similar papers in this journal
2
The Lancet Infectious Diseases
○ 73 papers in training set
Top 0.1%
7.8%
Similar papers in this journal
3
Nature Medicine
○ 125 papers in training set
Top 0.2%
7.2%
Similar papers in this journal
4
Science Translational Medicine
● 127 papers in training set
Top 0.2%
6.2%
Similar papers in this journal
5
Med
○ 39 papers in training set
Top 0.1%
6.2%
Similar papers in this journal
6
Nature
○ 645 papers in training set
Top 3%
5.5%
7
Cell Reports
○ 1498 papers in training set
Top 12%
3.2%
50% of probability mass above
8
Cell
○ 431 papers in training set
Top 3%
3.2%
9
The Journal of Infectious Diseases
◐ 202 papers in training set
Top 1%
3.1%
10
eBioMedicine
○ 183 papers in training set
Top 1%
2.7%
11
New England Journal of Medicine
● 52 papers in training set
Top 0.2%
2.6%
12
Cell Reports Medicine
○ 153 papers in training set
Top 1%
2.6%
13
Immunity
○ 67 papers in training set
Top 0.8%
2.4%
14
Science Immunology
● 88 papers in training set
Top 1%
2.4%
15
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 24%
2.1%
16
Science
● 477 papers in training set
Top 4%
2.1%
17
eLife
● 5828 papers in training set
Top 46%
2.1%
18
Vaccine
○ 203 papers in training set
Top 1%
1.7%
19
iScience
○ 1154 papers in training set
Top 18%
1.7%
20
Emerging Microbes & Infections
○ 74 papers in training set
Top 0.8%
1.4%
21
JAMA Network Open
● 130 papers in training set
Top 2%
1.4%
22
mBio
● 833 papers in training set
Top 8%
1.4%
23
npj Vaccines
○ 67 papers in training set
Top 0.6%
1.1%
24
Gut
● 40 papers in training set
Top 0.7%
1.1%
25
Cell Discovery
○ 57 papers in training set
Top 0.8%
1.0%
26
Frontiers in Immunology
○ 638 papers in training set
Top 8%
1.0%
27
Cell Host & Microbe
126 papers in training set
Top 2%
0.8%
28
Journal of Clinical Investigation
● 179 papers in training set
Top 6%
0.8%
29
Cancer Cell
○ 42 papers in training set
Top 1%
0.8%
30
Signal Transduction and Targeted Therapy
○ 30 papers in training set
Top 0.8%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.