Safety margin evaluations for transtympanic laser stimulation of the cochlea from the outer ear in Mongolian gerbils (Meriones unguiculatus)
Okamoto, A.; Uenaka, M.; Ito, Y.; Miyasaka, T.; Toda, K.; Hiryu, S.; Kobayasi, K. I.; Tamai, Y.
Show abstract
Infrared laser cochlear stimulation has been suggested as an alternative to traditional auditory prostheses. Previous research has mainly examined the short-term effects of laser stimulation, but to effectively use this technique, it is necessary to study whether prolonged laser exposure can safely and sustainably induce cochlear responses. This study assessed the effect of laser-induced cochlear damage using classically-conditioned Mongolian gerbils. The white noise was presented as a conditioned stimulus, and reward licking was recorded as a conditioned response. After training, the subjects cochlea was exposed to a continuous pulsed laser for 15 h. The licking rate drastically decreased after the exposure of 26.4 W/cm2, while it did not change after 6.6 W/cm2 or weaker. These findings showed, for the first time, that the safety margin of long-term, at least several hours, cochlear laser stimulation exists and will contribute to the safe and effective delimitation of laser parameters in future research.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Far-Ultraviolet Light Causes Direct DNA Damage in Human Lung Cells and Tissues 93%
- Cell viability assessment associated with a contact of gas bubbles produced by femtosecond laser breakdown in cell culture media 93%
- Multisensory interactions on auditory and somatosensory information in expert pianists 93%
Similar papers in this journal
- An integrated system for comprehensive mouse peripheral vestibular function evaluation based on Vestibulo-ocular Reflex 93%
- Differentiating Causes of Post-Surgical Conductive Hearing Loss with Optical Coherence Tomography Vibrometry 93%
- Anatomical integrity of the human cochlea estimated with optical coherence tomography for future clinical application 93%
Similar papers in this journal
- Pterostilbene Protects Cochlea from Ototoxicity in Streptozotocin-Induced Diabetic Rats by Inhibiting the Apoptosis 94%
- Biological responses to terahertz radiation with different power density in primary hippocampal neurons 93%
- Preclinical safety evaluation of continuous UV-A lighting in an operative setting 93%
Similar papers in this journal
- Focality of sound source placement by higher (9th) order ambisonics and perceptual effects of spectral reproduction errors 92%
- Intrasubject variability in Potential Early Markers of Sensorineural Hearing Damage 92%
- Air-Conduction And Bone-Conduction Reference Threshold Levels – A Multicenter Study 92%
Similar papers in this journal
- Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation 94%
- TRPV1-mediated sonogenetic neuromodulation of motor cortex in freely moving mice 93%
- Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.