Rho GTPase Activating Protein 15 (ARHGAP15) increases cancer risk in patients with diverticular disease
Lehrer, S.; Rheinstein, P.
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IntroductionPatients with diverticular disease who have colorectal histopathology, normal or abnormal, have increased risk of overall incident cancer. To determine whether the cancer risk might have a genetic basis, we performed a Genome Wide Association Study (GWAS) with data from UK Biobank. MethodsWe used PLINK 2, a whole-genome association analysis toolset, to analyze the UKB chromosome files. To identify cases, we used ICD10 code K57.3, diverticular disease of large intestine without perforation or abscess. We selected subjects younger than 45, since genetic forms of disease tend to manifest in younger patients. ResultsGWAS summary (Manhattan) plot of the meta-analysis association statistics, highlighting one susceptibility locus, Rho GTPase Activating Protein 15 (ARHGAP15), with genome wide significance for diverticulosis. ConclusionWe conclude that ARHGAP15 could be responsible for the association of diverticular disease and cancer.
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