Diverse genetic architectures on the Z chromosome underlie the two rules of speciation in Papilio butterfly hybrids
Xiong, T.; Tarikere, S.; Rosser, N.; Li, X.; Yago, M.; Mallet, J.
Show abstract
The fitness of animal hybrids follows two empirical rules: hybrids of the heterogametic sex aremore unfit (Haldanes Rule), and the sex chromosome is disproportionately involved in incompatibility (the large-X/Z effect). Whether these rules result from genetic mechanisms shared across taxa remains unknown, and existing explanations rarely consider female heterogametic taxa such as butterflies. Here, we investigate hybrid incompatibilities in Papilio and Heliconius butterflies, and show that defects coincide with unbalanced introgression between the Z chromosome and its genetic background. This polygenic mechanism predicts both rules because introgressed ancestry on the Z chromosome is more skewed in females, and is more variable than on all autosomes. Therefore, the explanation for both rules in butterflies shares little similarity with prevailing theories relying on dominance.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.