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GENLIB: new function to simulate haplotype transmission in large complex genealogies

Rakesh, M.; Vezina, H.; Laprise, C.; Freeman, E.; Burkett, K.; Roy-Gagnon, M.-H.

2022-10-28 bioinformatics
10.1101/2022.10.28.514245 bioRxiv
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SummaryFounder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a new function added to the genealogical analysis R package GENLIB, which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies. Availability and implementationThe new function is available in the latest version of the GENLIB package (v1.1.6), available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Stand-alone scripts for analyzing the output of the function can be accessed at https://github.com/R-GENLIB/simuhaplo_scripts.

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