TGF-β promotes the postselection thymic development and peripheral function of interferon-γ-producing iNKT cells
Morgan, R. C.; Frank, C.; Greger, M.; Sigvardsson, M.; Bartom, E. T.; Kee, B. L.
Show abstract
Interferon-{gamma} producing invariant natural killer T (iNKT1) cells are lipid reactive innate-like lymphocytes that are resident in the thymus and peripheral tissues where they protect against pathogenic infection. The thymic functions of iNKT1 cells are not fully elucidated but subsets of thymic iNKT cells modulate CD8 T cell, dendritic cell, B cell and thymic epithelial cell numbers or function. Here we show that a subset of thymic iNKT1 cells require transforming growth factor (TGF)-{beta} induced signals for their development and for expression of residency associated adhesion receptors. Liver and spleen iNKT1 cells do not share this TGF-{beta} gene signature but nonetheless TGF-{beta} is required for optimal liver iNKT1 cell function. Our findings provide insight into the heterogeneity of mechanisms guiding iNKT1 cell development in different tissues and suggest a close association between a subset of iNKT1 cells and TGF-{beta} producing cells in the thymus.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- SMAD4 and TGFβ are architects of inverse genetic programs during fate-determination of antiviral memory CD8 T cells 96%
- Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms 96%
- Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity 96%
Similar papers in this journal
- Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalling 96%
- The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling 95%
- Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification 95%
Similar papers in this journal
- High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision 97%
- Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes 95%
- Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling 95%
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.