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Genome sequencing of the Monkeypox virus 2022 outbreak with Amplicon-based Oxford Nanopore MinION sequencing

Brinkmann, A.; Pape, K.; Uddin, S.; Woelk, N.; Foerster, S.; Jessen, H.; Michel, J.; Kohl, C.; Schaade, L.; Nitsche, A.

2022-10-20 molecular biology
10.1101/2022.10.20.512862 bioRxiv
Show abstract

We present an amplicon-based assay for MinION Nanopore sequencing of monkeypox virus genomes from clinical specimens, obtaining high-quality results for up to 99 % of the genomes, even for samples with high Ct values of up to 30 which are not suitable for shotgun sequencing.

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