Breadth of Fc-mediated effector function delineates grades of clinical immunity following human malaria challenge
Nkumama, I. N.; Odera, D.; Musasia, F.; Mwai, K.; Nyamako, L.; Murungi, L.; Tuju, J.; Furle, K.; Rosenkranz, M.; Kimathi, R.; Njuguna, P.; Hamaluba, M.; Kapulu, M. C.; Frank, R.; CHMI-SIKA Study Team, ; Osier, F.
Show abstract
Controlled human malaria challenge studies in semi-immune volunteers provide an unparalleled opportunity to robustly identify mechanistic correlates of protection. We leveraged this platform to undertake a head-to-head comparison of seven functional antibody assays that are relevant to immunity against the erythrocytic merozoite stage of Plasmodium falciparum. Fc-mediated effector functions were strongly associated with protection from clinical symptoms of malaria and exponential parasite multiplication while the gold standard growth inhibition assay was not. The breadth of Fc-mediated effector function clearly discriminated grades of clinical immunity following challenge. These findings present a paradigm shift in the understanding of the mechanisms that underpin immunity to malaria and have important implications for vaccine development.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A baseline transcriptional signature associates with clinical malaria risk in RTS,S/AS01-vaccinated African children 95%
- Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in Plasmodium falciparum 94%
- BIRC6 modifies risk of invasive bacterial infection in Kenyan children 94%
Similar papers in this journal
- Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites 96%
- Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity 95%
- Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype 94%
Similar papers in this journal
Similar papers in this journal
- Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 95%
- Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum : safety and parasite growth dynamics 94%
- Impact of a rapid decline in malaria transmission on antimalarial IgG subclasses and avidity 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.