Cytoophidia maintain the integrity of Drosophila follicle epithelium
Wang, Q.-Q.; You, D.-D.; Liu, J.-L.
Show abstract
CTP synthase (CTPS) forms a filamentous structure termed the cytoophidium in all three domains of life. The female reproductive system of Drosophila is an excellent model for studying the physiological function of cytoophidia. Here, we use CTPSH355A, a point mutation that destroys the cytoophidium-forming ability of CTPS, to explore the in vivo function of cytoophidia. In CTPSH355A egg chambers, we observe the ingression and increased heterogeneity of follicle cells. In addition, we find that the cytoophidium-forming ability of CTPS, rather than the protein level, is the cause of the defects observed in CTPSH355A mutants. To sum up, our data indicate that cytoophidia play an important role in maintaining the integrity of follicle epithelium.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The function of juvenile-adult transition axis in female sexual receptivity of Drosophila melanogaster 96%
- Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone 95%
- Differential modifications of the C-terminal tails of α-tubulin isoforms and their importance for kinesin-based microtubule transport in vivo 94%
Similar papers in this journal
- The PAF1 complex cell-autonomously promotes oogenesis in Caenorhabditis elegans 96%
- Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole 94%
- Chromosome counting in the mouse zygote using low-invasive super-resolution live-cell imaging 93%
Similar papers in this journal
- Kinome-wide RNAi screen uncovers role of Ballchen in maintenance of gene activation by trithorax group in Drosophila 94%
- Canonical Wnt signaling promotes formation of somatic permeability barrier for proper germ cell differentiation 94%
- Transcriptomic Analysis of the Spatiotemporal Axis of Oogenesis and Fertilization in C. elegans 93%
Similar papers in this journal
- The transcription factor Capicua maintains the oocyte polarity in the panoistic ovary of the German cockroach. 94%
- The Caenorhabditis elegans spe-21 gene that encodes a palmitoyltransferase is necessary for spermiogenesis. 93%
- FGF signalling is involved in cumulus migration in the common house spider Parasteatoda tepidariorum 93%
Similar papers in this journal
- Analysis of molecular and cellular bases of honey bee mushroom body development 96%
- Actin bundles play different role in shaping scale as compare to bristle in mosquito Aedes aegypti. 95%
- Sequential accumulation of dynein and its regulatory proteins at the spindle region in the Caenorhabditis elegans embryo 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.