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Re-evaluating the robustness of Mendelian randomisation to measurement error

2022-10-04 epidemiology Title + abstract only
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BackgroundMendelian randomisation (MR) uses germline genetic variation as a natural experiment to investigate causal relations between traits. MR is robust to non-differential random measurement error in exposures or outcomes. However, the effect of differential measurement error, and non-differential measurement error on the variant selection process, remains unclear. MethodsWe use Monte-Carlo simulations and an applied example to explore the effect of differential measurement error on MR esti...

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