Global patterns and correlates in the emergence of antimicrobial resistance in humans
Mendelsohn, E.; Ross, N.; Zambrana-Torrelio, C.; Van Boeckel, T.; Laxminarayan, R.; Daszak, P.
Show abstract
Antimicrobial resistance (AMR) is a critical global health threat, and drivers of the emergence of novel strains of antibiotic-resistant bacteria in humans are poorly understood at the global scale. We examined correlates of AMR emergence in humans using global data on the origins of novel strains of AMR bacteria from 2006 to 2017, human and livestock antibiotic use, country economic activity, and reporting bias indicators. We found that AMR emergence is positively correlated with antibiotic consumption in humans, whereas the relationship with antibiotic consumption in livestock is modified by gross domestic product (GDP), with only higher GDP countries showing a slight positive association. We also found that human travel may play a role in AMR emergence, likely driving the spread of novel AMR strains into countries where they are subsequently detected for the first time. Finally, we produced predictive models and country-level maps of the global distribution of AMR risk. We assessed these against spatial patterns of reported AMR emergence, to identify gaps in surveillance that can be used to direct prevention and intervention policies.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Revealing the drivers of antibiotic resistance trends in Streptococcus pneumoniae amidst the 2020 COVID-19 pandemic: Insights from mathematical modeling 93%
- Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes 93%
- Quantifying antibiotic impact on within-host dynamics of extended-spectrum beta-lactamase resistance in hospitalized patients 92%
Similar papers in this journal
Similar papers in this journal
- Geographic spillover of antimicrobial resistance from mass distribution of azithromycin 91%
- Allergic to Confounding: Leveraging Penicillin Allergy as an Instrumental Variable to Estimate the Causal Effect of Antibiotic Use on Resistance 90%
- Increased Transmissibility of SARS-CoV-2 Lineage B.1.1.7 by Age and Viral Load: Evidence from Danish Households 90%
Similar papers in this journal
- MACREL: antimicrobial peptide screening in genomes and metagenomes 89%
- Transmission potential of mpox in Mainland China, June-July 2023: estimating reproduction number during the initial phase of the epidemic 89%
- Bridging the TB data gap: in silico extraction of rifampicin-resistant tuberculosis diagnostic test results from whole genome sequence data 88%
Similar papers in this journal
- Impact of climate change on diarrhoea risk in low- and middle-income countries 90%
- Antimicrobial resistance landscape in a metropolitan city context using open drain wastewater-based metagenomic analysis 86%
- Comparison of pandemic excess mortality in 2020-2021 across different empirical calculations 86%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.