Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE following helminth infection
Curtiss, M. L.; Rosenberg, A. F.; Scharer, C. D.; Benavides, N. A. B.; Bradley, J. E.; Leon, B.; Steele, C. C.; Randall, T. D.; Lund, F. E.
Show abstract
Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for the chitinase-like protein ChI3L1 in allergic disease. To address whether CHI3L1 also contributes to TH2 responses following nematode infection, we infected Chi3l1-/- mice with Heligmosomoides polygyrus (Hp) and analyzed T cell responses. Not surprisingly, we observed impaired TH2 responses in Hp-infected Chi3l1-/- mice. However, we also found that T cell intrinsic expression of Chi3l1 was required for ICOS upregulation following activation of naive CD4 T cells and was necessary for the development of the IL-4+ TFH subset, which supports germinal center (GC) B cell reactions and IgE responses. The requirement for Chi3l1 in TFH and IgE responses was also seen following alum-adjuvanted vaccination. While Chi3l1 was critical for IgE humoral responses it was not required for vaccine or infection induced IgG1 responses. These results suggest that Chi3l1 specifically modulates IgE responses that are highly dependent on help from IL-4-producing TFH cells.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Redefining CD4 T cell residency: Helper T cells orchestrate protective humoral immunity in the lung 97%
- cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory 96%
- The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication 96%
Similar papers in this journal
- T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling 96%
- Integration of Avidity and Differentiation is enabled by CD8+ T-cell sensing of IFN-γ 96%
- Metformin enhances anti-mycobacterial responses by educating immunometabolic circuits of CD8+ T cells 96%
Similar papers in this journal
- Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism 97%
- Regulatory T cells control the dynamic and site-specific polarization of CD4 T cells following Salmonella infection 96%
- Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling 96%
Similar papers in this journal
Similar papers in this journal
- Cell-intrinsic functions of the transcription factor Bhlhe40 in activated B cells and T follicular helper cells restrain the germinal center reaction and prevent lymphomagenesis 97%
- TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming 96%
- HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.