Crossing-over decision landscape in maize
Zelkowski, M.; Wang, M.; Sun, Q.; Pillardy, J.; Kianian, P. M.; Kianian, S.; Chen, C.; Pawlowski, W. P.
Show abstract
In most crops, including maize, meiotic double-strand breaks (DSBs) occur in all chromosome regions but crossovers (COs) are predominantly near chromosome ends. To understand how the uniform DSB distribution changes into the U-shaped CO distribution, we generated high-resolution maps of CO intermediates. We found that DSBs with medium resection spans more often result in COs than those with shorter or longer resections. We also discovered that sites of CO intermediates associated with MLH3 in zygotene are uniformly distributed along chromosomes, resembling DSB distribution. However, in late prophase, they show the U-shaped distribution characteristic of COs. While zygotene MLH3 sites exhibit methylation levels similar to the genome average, late prophase sites have reduced DNA methylation. In contrast to DNA methylation, inter-parental DNA sequence polymorphism has limited effect on CO distribution. These data indicate that the final CO landscape shape in maize is established late during recombination and controlled by chromatin state.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Large domains of heterochromatin direct the formation of short mitotic chromosome loops 95%
- The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons 95%
- The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in C. elegans 95%
Similar papers in this journal
- The maize gene maternal derepression of r1 (mdr1) encodes a DNA glycosylase that demethylates DNA and reduces siRNA expression in endosperm 96%
- Heat stress reveals the existence of a specialized variant of the pachytene checkpoint in meiosis of Arabidopsis thaliana 96%
- Systematic histone H4 replacement in Arabidopsis thaliana reveals a role for H4R17 in regulating flowering time 95%
Similar papers in this journal
- ZmMTOPVIB is essential for double-strand break formation and bipolar spindle assembly in maize meiosis 96%
- Interfered Chromosome Pairing Promotes Meiosis Instability of Autotetraploid Arabidopsis by High Temperatures 95%
- Sex chromosome pairing and multivalent associations during meiosis in diploid and polyploid Silene latifolia 94%
Similar papers in this journal
Similar papers in this journal
- MDR1 DNA glycosylase regulates the expression of genomically imprinted genes and helitrons 96%
- A Common Resequencing-Based Genetic Marker Dataset for Global Maize Diversity 95%
- Two CENH3 paralogs in the green alga Chlamydomonas reinhardtii have a redundantly essential function and associate with ZeppL-LINE1 elements 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.