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Dose of approved COVID-19 vaccines is based on weak evidence: a review of early-phase, dose-finding trials

2022-09-22 infectious diseases Title + abstract only
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Although over 12 billion COVID-19 vaccine doses have been administered globally, the important issue of whether the optimal doses are being used has been relatively neglected. To address this question, we reviewed the reports of early-phase dose-finding trials of the nine COVID-19 vaccines approved by World Health Organization (and one additional vaccine which showed partial clinical efficacy), extracting information on study design and findings on reactogenicity and early humoral immune respons...

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