Non-invasive temporal interference electrical stimulation of the human hippocampus
Violante, I. R.; Alania, K.; Cassara, A. M.; Neufeld, E.; Acerbo, E.; Carron, R.; Williamson, A.; Kurtin, D. L.; Rhodes, E.; Hampshire, A.; Kuster, N.; Boyden, E. S.; Pascual-Leone, A.; Grossman, N.
Show abstract
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders however its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modelling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging (fMRI) and behaviour experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Integrating electric field modelling and neuroimaging to explain inter-individual variability of tACS effects 97%
- Role of Thalamus in Human Conscious Perception Revealed by Low-Intensity Focused Ultrasound Neuromodulation 96%
- Lateral Prefrontal Theta Oscillations Causally Drive a Computational Mechanism Underlying Conflict Expectation and Adaptation 96%
Similar papers in this journal
- Prefrontal stimulation prior to motor sequence learning alters multivoxel patterns in the striatum and the hippocampus 96%
- Temporal order of activations and interactions during arithmetic calculations measured by intracranial electrophysiological recordings in the human brain 96%
- Reliability of brain metrics derived from a Time-Domain Functional Near-Infrared Spectroscopy System 95%
Similar papers in this journal
- Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory 96%
- Omissions of Threat Trigger Subjective Relief and Prediction Error-Like Signaling in the Human Reward and Salience Systems 96%
- THINGS-data: A multimodal collection of large-scale datasets for investigating object representations in human brain and behavior 96%
Similar papers in this journal
- Transcranial electric stimulation modulates firing rate at clinically relevant intensities 96%
- Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity 95%
- TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study 95%
Similar papers in this journal
- tDCS modulates effective connectivity during motor command following; a potential therapeutic target for disorders of consciousness 96%
- Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI 96%
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.