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Examining the evidence for Mendelian randomization homogeneity assumption violation using instrument association with exposure variance

2022-09-15 epidemiology Title + abstract only
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BackgroundEstimation of the average causal effect using instrumental variable (IV) analyses requires homogeneity of instrument-exposure and/or exposure-outcome relationships. Previous research explored the validity of homogeneity assumptions by testing IV-exposure interaction effects using a set of effect modifiers. However, this approach requires that modifiers are known and measured but evidence for interaction may also be observed through IV association with exposure variance without knowledg...

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