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Fingolimod for treatment and or prevention of chemotherapy-induced peripheral neuropathy in humans?

2022-09-09 oncology Title + abstract only
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PurposeSubstantial preclinical data support that fingolimod, a drug that dysregulates sphingolipid metabolism, could both prevent chemotherapy-induced neuropathy (CIPN) and treat established chemotherapy-induced neuropathy. MethodsTwo pilot-phase clinical trials were developed to evaluate whether fingolimod could 1) inhibit the development of paclitaxel-induced peripheral neuropathy and 2) diminish established CIPN in humans. ResultsUnfortunately, both clinical trials were not able to fulfill ...

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