Enterococcal linear plasmids adapt to Enterococcus faecium and spread within multidrug-resistant clades.
Hashimoto, Y.; Suzuki, M.; Kobayashi, S.; Hirahara, Y.; Nomura, T.; Kurushima, J.; Hirakawa, H.; Tanimoto, K.; Tomita, H.
Show abstract
Antimicrobial resistance (AMR) of bacterial pathogens, including enterococci, is a global concern, and plasmids are crucial for spreading and maintaining AMR genes. Plasmids with linear topology were recently identified in clinical multidrug-resistant enterococci. The enterococcal linear-form plasmids, such as pELF1, confer resistance to clinically important antimicrobials, including vancomycin; however, little information exists about their epidemiological and physiological effects. In this study, we identified several lineages of enterococcal linear plasmids that are structurally conserved and occur globally. pELF1-like linear plasmids show plasticity in acquiring and maintaining AMR genes, often via transposition with the mobile genetic element IS1216E. This linear plasmid family has several characteristics enabling long-term persistence in the bacterial population, including high horizontal self-transmissibility, low-level transcription of plasmid-encoded genes, and a moderate effect on the Enterococcus faecium genome alleviating fitness cost and promoting vertical inheritance. Combined with its broad host range, the linear plasmid is an important factor in the spread and maintenance of AMR genes among enterococci.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Genetic Determinants of pOXA-48 Plasmid Maintenance and Propagation in Escherichia coli 97%
- Large-scale network analysis captures biological features of bacterial plasmids 96%
- Construction of a complete set of Neisseria meningitidis defined mutants - the NeMeSys 2.0 collection - and its use for the phenotypic profiling of the genome of an important human pathogen 96%
Similar papers in this journal
- Genomic diversity of hospital-acquired infections revealed through prospective whole genome sequencing-based surveillance 96%
- Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins 95%
- Preparation of functional metagenomic libraries from low biomass samples using METa assembly and their application to capture antibiotic resistance genes 94%
Similar papers in this journal
- A Plasmid Network from the Gut Microbiome of Semi-isolated Human Groups Reveals Unique and Shared Metabolic and Virulence Traits 94%
- Genomic epidemiology of vancomycin resistant Enterococcus faecium (VREfm) in Latin America: Revisiting the global VRE population structure 94%
- High diversity and variability of pipolins among a wide range of pathogenic Escherichia coli strains 93%
Similar papers in this journal
- Genomic surveillance of vancomycin-resistant Enterococcus faecium reveals spread of a linear plasmid conferring a nutrient utilization advantage 97%
- Phage-plasmids spread antibiotic resistance genes through infection and lysogenic conversion 95%
- Evolutionary processes driving the rise and fall of Staphylococcus aureus ST239, a dominant hybrid pathogen 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.