Brain-Based Gene Expression of Putative Risk Genes for Anorexia Nervosa in the Human Brain
Murray, S.; Rokicki, J.; Sartorius, A.; Winterton, A.; Andreassen, O.; Westlye, L. T.; Nagata, J. M.; Quintana, D. S.
Show abstract
The etiology of anorexia nervosa (AN) remains elusive. Here, we characterize spatially distributed expression patterns of risk genes for AN in the human brain, developing whole-brain maps of AN gene expression. We found that genes associated with AN are most expressed in the brain, relative to all other body tissue types, and demonstrate gene-specific expression patterns which extend to cerebellar, limbic and basal ganglia structures in particular. fMRI meta-analyses reveal that AN gene expression maps correspond with functional brain activity involved in processing and anticipating appetitive and aversive cues.
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