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The SumRank method efficiently detects valid pleiotropic variants using GWAS summary level data

2022-09-09 epidemiology Title + abstract only
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Cross-trait analyses are a powerful approach for refining our understanding of the genetic architectures underlying complex traits. Although many cross-trait association methods exist, a systematic evaluation of their performance is lacking. We compare true and false positive rates of several other methods using numerical (up to 300 traits) and genotype (up to 4 traits) simulations and introduce a new cross-trait association method, SumRank. For two traits, ConjFDR, SumRank, and GPA showed high ...

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