Disrupted role of the connectivity between the locus coeruleus and the hippocampus in cognition of healthy, middle-aged individuals at risk of dementia: the PREVENT-Dementia study
Deng, F.; Dounavi, M.-E.; Ritchie, K.; Muniz-Terrera, G.; Malhotra, P.; Ritchie, C. W.; Lawlor, B.; Naci, L.
Show abstract
Alzheimers Disease (AD) neuropathology start decades before clinical manifestations, but whether risk factors are associated with early cognitive and brain changes in midlife remains poorly understood. We examined whether AD risk factors were associated with cognition and functional connectivity (FC) between the Locus Coeruleus (LC) and hippocampus - two key brain structures in AD neuropathology - cross-sectionally and longitudinally in cognitively healthy midlife individuals. Neuropsychological assessments and functional Magnetic Resonance Imaging were obtained at baseline (N=210), and two-years follow-up (N=188). Associations of cognition and FC with apolipoprotein {varepsilon}4 (APOE {varepsilon}4) genotype, family history of dementia, and the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score were investigated. Cross-sectionally, higher CAIDE scores were associated with worse cognition. Menopausal status interacted with the CAIDE risk on cognition. Furthermore, the CAIDE score significantly moderated the relationship between cognition and LC-Hippocampus FC. Longitudinally, the LC-Hippocampus FC decreased significantly over 2 years. These results shed light on some of the earliest effects of AD risk on cognition and the brain.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Metacognition, cortical thickness, and tauopathy in aging 98%
- Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers 98%
- Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia 97%
Similar papers in this journal
- Social isolation is linked to declining grey matter structure and cognitive functions in the LIFE-Adult panel study 97%
- Biological Brain Age Prediction Using Machine Learning on Structural Neuroimaging Data: Multi-Cohort Validation Against Biomarkers of Alzheimer’s Disease and Neurodegeneration stratified by sex 95%
- Neurophysiological trajectories in Alzheimer's disease progression 95%
Similar papers in this journal
- A residual marker of cognitive reserve is associated with resting-state intrinsic functional connectivity along the Alzheimer’s disease continuum 96%
- Obesity-related brain atrophy occurs through mechanisms independent of Alzheimer’s disease pathology 96%
- Neural mechanisms of disease pathology and cognition in young-onset Alzheimer’s Disease variants 94%