Super-resolution imaging reveals dynamic skeletal cytoophidia
Fang, Y.; Li, Y.-L.; Li, X.-M.; Liu, J.-L.
Show abstract
CTP synthase (CTPS) can form filamentous structures termed cytoophidia in cells from all three domains of life. In order to study the mesoscale structure of cytoophidia, we perform fluorescence recovery after photobleaching (FRAP) and stimulated emission depletion (STED) microscopy in human cells. By using EGFP dimeric tag, as a tool to explore the physical properties of cytoophidia, we find that cytoophidia are dynamic and reticular. The reticular structure of CTPS cytoophidia may provide space for other components such as IMPDH. In addition, we observe CTPS granules with tentacles.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization 91%
- PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomalhomeostasis 91%
- OpenEMMU: a versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics 91%
Similar papers in this journal
- Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity 94%
- BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation 92%
- Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions 91%
Similar papers in this journal
- Membrane stretching activates calcium-permeability of a putative channel Pkd2 during fission yeast cytokinesis 92%
- Loss of CHMP2A implicates an ordered assembly of ESCRT-III proteins during cytokinetic abscission 92%
- Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.