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Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension
Ali, M. K.; Liu, Y.; Wu, J. C.; Perez, V. d. J.; Rhodes, C. J.; Cao, A.; Wilkins, M. R.; Nicolls, M. R.; Spiekerkoetter, E. F.
2022-08-27
cell biology
10.1101/2022.08.27.505495
bioRxiv
Show abstract
This study shows that the long non-coding RNA RGMB-AS1 is upregulated in the blood and pulmonary vascular cells of PAH patient and that it regulates BMPR2 signaling. Inhibiting RGMB-AS1 increases BMPR2 signaling and improves pulmonary vascular cell function.
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