Productive and latent HIV infections originate in resting CD4+ T cells
Wietgrefe, S.; Anderson, J.; Duan, L.; Southern, P. J.; Zuck, P.; Wu, G.; Howell, B.; Reilly, C.; Kroon, E.; Chottanapund, S.; Buranapraditkun, S.; Sacdalan, C.; Tulmethakaan, N.; Colby, D. J.; Chomchey, N.; Prueksakaew, P.; Pinyakorn, S.; Trichavaroj, R.; Hsu, D.; Vasan, S.; Manasnayakorn, S.; de Souza, M.; Tovanabutra, S.; Schuetz, A.; Robb, M. L.; Phanuphak, N.; Ananworanich, J.; Schacker, T.; Haase, A. T.
Show abstract
Productively and latently HIV-infected cells are the source of virus that respectively establishes and sustains systemic infections and the reservoir in which HIV persists and rebounds when anti-retroviral therapy (ART) is interrupted. While infected activated CD4+ T cells are thought to be the principal source of HIV production, and reversion of activated infected cells to a resting state as the major pathway to establishment of the latently infected cell reservoir, we now show that in the earliest stages of detectable HIV infection in the lymphoid tissue reservoir, infection of resting CD4+ T cells establishes the first populations of both productively and latently infected cells. We further show that the early infection of resting T cells reflects their predominance in lymphoid tissues and the expression of pTEFb in vivo in resting T cells to support their infection. The immediate establishment of productively and latently infected cell populations enable HIV to propagate and persist, and generates reservoirs from which infection can rebound despite instituting ART at the earliest stage of detectable infection.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A novel high throughput microwell outgrowth assay for HIV infected cells 94%
- Comprehensive maps of escape mutations from antibodies 10-1074 and 3BNC117 for Envs from two divergent HIV strains 94%
- Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice 94%
Similar papers in this journal
- Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy 95%
- Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection 94%
- The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load and total HIV-1 DNA in HIV-1 infected humanized mice 93%
Similar papers in this journal
- Characterization and comparison of immunity against MPXV for individuals infected with MPXV or vaccinated with modified vaccinia Ankara vaccines 92%
- CD3+ T-cell: CD14+monocyte complexes are dynamic and increased with HIV and glucose intolerance 91%
- Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence 91%
Similar papers in this journal
Similar papers in this journal
- Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV 94%
- Pre-Human Immunodeficiency Virus (HIV) infection Th17 CD4+ T cells as predictors of early HIV disease progression 94%
- CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.