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Assessing the impact of limit of detection on HAI titer increase estimation in vaccine studies

2022-08-30 epidemiology Title + abstract only
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In many laboratory assays that measure immunological quantities, a portion of the measured values fall below a limit of detection (LOD). This is also the case for the hemagglutination inhibition assay (HAI), a common method used to quantify antibodies in influenza research. The conventional approach is to treat values below the LOD as either equal to the LOD or LOD/2, which can introduce potential biases. These biases can become more pronounced when calculating compound measures such as the diff...

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