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RNA Immunoprecipitation and Sequencing of Isolated RNAs (RIP-SIR) Identifies Endogenous miRNA-Target Interactions

Wells, J.; SRIVASTAVA, A.; Maser, R. S.; Kesharwani, R.; Sarsani, V. K.; Daigle, S. L.; Lynch, R. P.; Munger, H. J.; Doty, R.; Saxl, R. L.; Bult, C. J.

2022-08-22 molecular biology
10.1101/2022.08.22.504764 bioRxiv
Show abstract

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression in species ranging from plants to mammals. Unraveling the complex networks of miRNA-mediated regulation of gene expression requires the ability to identify the mRNA targets of individual miRNAs in native cellular contexts. Here we describe RIP-SIR, an unbiased genome-wide method for identifying interactions between endogenous miRNAs and their targets in almost any tissue or cell type.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.