E. faecalis acquires resistance to antimicrobials and insect immunity via common mechanisms
Wadhawan, A.; Simoes da Silva, C. J.; Nunes, C. D.; Edwards, A. M.; Dionne, M. S.
Show abstract
Enterococcus faecalis is a normal member of the gut microbiota and an opportunistic pathogen of many animals, including mammals, birds, and insects. It is a common cause of nosocomial infections, and is particularly troublesome due to extensive intrinsic and acquired antimicrobial resistance. Using experimental evolution, we generated Drosophila-adapted E. faecalis strains, which exhibited immune resistance, resulting in increased in vivo growth and virulence. Resistance was characterised by mutations in bacterial pathways responsive to cell envelope stress. Drosophila-adapted strains exhibited changes in sensitivity to relevant antimicrobials, including daptomycin and vancomycin. Evolved daptomycin-resistant strains harboured mutations in the same signalling systems, with some strains showing increased virulence similar to Drosophila-adapted strains. Our results show that common mechanisms provide a route to resistance to both antimicrobials and host immunity in E. faecalis and demonstrate that the selection and emergence of antibiotic resistance in vivo does not require antibiotic exposure. One sentence summaryHost interaction can promote antimicrobial resistance and antimicrobial treatment can promote virulence in E. faecalis.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae 96%
- Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons 95%
- Neural mechanisms of parasite-induced summiting behavior in 'zombie' Drosophila 95%
Similar papers in this journal
- IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission 96%
- Infection increases activity via Toll dependent and independent mechanisms in Drosophila melanogaster 95%
- Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways 95%
Similar papers in this journal
- Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. 94%
- YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth. 94%
- Molecular evolution of CO2-sensing ab1C neurons underlies divergent sensory responses in the Drosophila suzukii species group 94%
Similar papers in this journal
- Step-specific adaptation and trade-off over the course of an infection by GASP-mutation small colony variants 95%
- Drosophila antimicrobial peptides and lysozymes regulate gut microbiota composition and abundance 94%
- Antifungal tolerance and resistance emerge at distinct drug concentrations and rely upon different aneuploid chromosomes 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.