Cellular profiling of a recently-evolved social behavior
Johnson, Z. V.; Hegarty, B. E.; Gruenhagen, G. W.; Lancaster, T. J.; McGrath, P. T.; Streelman, J. T.
Show abstract
Social behaviors are essential for survival and reproduction and vary within and among species. We integrate single nucleus RNA-sequencing (snRNA-seq), comparative genomics, and automated behavior analysis to investigate a recently-evolved social "bower building" behavior in Lake Malawi cichlid fishes. We functionally profile telencephalic nuclei matched to 38 paired behaving/control individuals. Our data suggest bower behavior has evolved in part through divergence in a gene module selectively expressed in a subpopulation of glia lining the pallium. Downregulation of the module is associated with glial departure from quiescence and rebalancing of neuronal subpopulation proportions in the putative homologue of the hippocampus. We show further evidence that behavior-associated excitation of neuronal populations that project to the putative hippocampus mediate glial function and rebalancing. Our work suggests that bower behavior has evolved through changes in glia and region-specific neurogenesis, and more broadly shows how snRNA-seq can generate insight into uncharted behaviors and species.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- New Hydra Genomes Reveal Conserved Principles of Hydrozoan Transcriptional Regulation 94%
- Cell type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis tumor stem-cell like cells 94%
- Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals 94%
Similar papers in this journal
- Examination of germline and somatic intercellular bridges in Hydra vulgaris reveals insights into the evolutionarily conserved mechanism of intercellular bridge formation 94%
- Evolutionary changes in the chromatin landscape contribute to reorganization of a developmental gene regulatory network during rapid life history divergence in sea urchins 93%
- Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw 93%
Similar papers in this journal
- Expression of FoxP2 in the Basal Ganglia Regulates Vocal Motor Sequences in the Adult Songbird 95%
- Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila 94%
- Intestine-enriched apolipoprotein b orthologs are required for stem cell differentiation and regeneration in planarians 94%
Similar papers in this journal
- Molecular patterns of evolutionary changes throughout the whole nervous system of multiple nematode species 95%
- Mosaic heterochrony in neural progenitors sustains accelerated brain growth and neurogenesis in the juvenile killifish N. furzeri 95%
- A sex-specific switch in a single glial cell patterns the apical extracellular matrix 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.